English
In the vast field of pharmaceutical research, CAS: 151-21-3, also known as Sodium Lauryl Sulfate (SLS), with its unique physicochemical properties and wide application potential, has become an indispensable component. As a commonly used pharmaceutical excipient, SLS plays a crucial role in the preparation of drug formulations, and also shows excellent performance in fields such as drug analysis, antibacterial, and antistatic. This paper will explore in depth SLS (CAS: 151-21-3) in multiple applications in pharmaceutical research, providing valuable references for researchers and producers in related fields.
CAS: 151-21-3, also known as Sodium Lauryl Sulfate (C12H25SO4Na), is a mixture with Sodium Lauryl Sulfate as the main component. Its good water solubility, moderate pH value range, high melting point, and high HLB value (about 40), provide a basis for its wide application in pharmacy. Additionally, its precise surface tension and critical micelle concentration data, also provide scientific evidence for the precise control of SLS in formulation processes.
Improving Disintegration Performance
In tablet preparation, CAS: 151-21-3 acts as a disintegrant, significantly improving the wettability and dissolution rate of tablets, promoting the rapid disintegration of tablets. Studies have shown, compared with single disintegrants, SLS used in combination with dry starch, can more effectively shorten the disintegration time of tablets, enhancing drug release efficiency.
Exploration of Antibacterial Effects
SLS also shows noteworthy antibacterial effects. It can disrupt the cell membrane structure, demonstrating significant antibacterial activity, particularly against Gram-positive bacteria like Staphylococcus aureus. In disinfectant formulations, the acetylpropionic acid-SLS complex has been verified to have a killing effect on various pathogens, providing new high-efficiency antibacterial strategies for the pharmaceutical field.
Optimization of Lubrication Effects
During the preparation of solid formulations, SLS is also used as a lubricant, reducing friction between particles, improving powder flowability, thereby enhancing the compressibility of formulations. Compared to traditional lubricants like magnesium stearate, SLS maintains lubrication efficiency, while also improving the dissolution of tablets in vitro, providing new options for formulation process optimization.
Unique Contributions to Antistatic Effects
In pellet coating, CAS: 151-21-3 also cannot be overlooked for its antistatic effects. During the coating process, SLS addition can effectively eliminate static electricity, ensuring smooth coating, and improving coating quality. This characteristic gives SLS unique application value in the preparation of pellet formulations.
With the deepening evaluation of generic drug consistency work, the role of pharmaceutical excipients in formulations is becoming increasingly prominent. SLS (CAS: 151-21-3) as a multifunctional excipient, shows excellent performance in solubilization, penetration promotion, antibacterial, lubrication, and antistatic aspects. In the future, with continuous research and technological advancements, SLS will be more widely and deeply applied in the pharmaceutical field, contributing more to the development of the pharmaceutical industry.
In conclusion, CAS: 151-21-3 is applied in many aspects and in-depth in the field of pharmaceutical research, its unique physicochemical properties and broad application prospects make it an important role in pharmaceutical research. We look forward to further exploring SLS potential in future research, injecting new vitality into the pharmaceutical business development.
